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title: "Module Functional Analysis"
canonical: "https://help.biobam.com/space/OUM3/3675861475/Module%20Functional%20Analysis"
format: markdown
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The OmicsBox Functional Analysis module is a well-known comprehensive bioinformatics tool for functional annotation. High-Throughput Blast and InterProScan : Utilize CloudBlast and CloudInterProScan for rapid sequence alignments and domain searches against customizable reference datasets.  Gene Ontology Mapping:  Link potential homologs and domains with available functional annotation from the latest well-curated databases provided by UniProt and Gene Ontology consortia. Blast2GO Annotation:  The Blast2GO methodology allows to flexibly assign the most reliable functional labels to novel sequence datasets, taking into account source annotation quality and ontology hierarchies. Enrichment Analysis:  Use different enrichment analysis approaches (Fisher Exact Test and GSEA) to identify over and under-represented molecular functions.  Combined Pathway Analysis:  Identify Reactome and KEGG pathways for any set of sequences, utilize the differential expression data to compute pathway enrichment using (GSEA), and benefit from a combined visualization for easier insights.   Functional Analysis Module Menu Additional Resources Functional Annotation Analysis use case:   . Functional Analysis Example Dataset:  https://resources.biobam.com/omicsbox/example_data/version_2_0_0/FunctionalAnalysis.zip